The CAPSID team organizes a seminar. The researcher Wim Vranken from the Université Libre de Bruxelles (VUB) and Graham Kemp from Gothenburg will give a talk
on Friday 23rd February at LORIA in room A006.
10:30 Wim Vranken (Vrije Universiteit Brussel)
Capturing the ambiguous behaviour of proteins from sequence-based predictions.
Protein conformations are not fixed in time, and conformational transitions are often essential for protein functionality. In addition, many of the as yet uncharacterised proteins in the ‘dark proteome’ likely exhibit conformational behaviour that cannot be captured by discrete conformational states. With our work, we aim to create a more probabilistic picture of protein behaviour that requires only their sequence. We predict per-amino acid residue biophysical characteristics such as dynamics, conformation and capacity for early folding, as influenced by the local sequence environment. The approach is applicable to any protein, and can be further combined with evolutionary information in an attempt to better understand the capacity proteins have for ambiguous and complex behaviour.