Francesco Givaninni, PhD student in Neurosys team, will defend his PhD on Tuesday the 19th of September at 13h30 in the Amphitheatre C. The subject is “Mathematical Modelling of Neural Oscillations in Hippocampal Memory Networks during Waking and under General Anaesthesia”.
Memory is commonly defined as the ability to encode, store, and recall information we perceived. As we experience the world, we sense stimuli, we witness events, we ascertain facts, we study concepts, and we acquire skills. Although memory is an innate and familiar human behaviour, the interior workings of the brain which provide us with such faculties are far from being fully unravelled. Experimental studies have shown that during memory tasks, certain brain structures exhibit synchronous activity which is thought to be correlated with the short-term maintenance of salient stimuli. The objective of this thesis is to use biologically-inspired mathematical modelling and simulations of neural activity to shed some light on the mechanisms enabling the emergence of these memory-related synchronous oscillations. We focus in particular on hippocampal mnemonic activity during the awake state, and the amnesia and paradoxical memory consolidation occurring under general anaesthesia.